Do not take Fluconazole 150 mg Capsules if you are

• allergic to fluconazole, or to a similar medicine you have taken to treat a fungal infection or thrush or any of the other ingredients of this medicine (listed in section 6). The symptoms may include itching, reddening of the skin or difficulty in breathing
• taking astemizole, terfenadine (antihistamine medicines for allergies)
• taking cisapride (used for stomach upsets)
• taking pimozide (used for treating mental illness)
• taking quinidine (used for treating heart arrhythmia)
• taking erythromycin (an antibiotic for treating infections)

Warnings and precautions

Talk to your doctor or pharmacist before taking Fluconazole 150 mg Capsules if you

• have any disease or illness affecting your liver or kidneys
• suffer from heart disease, including heart rhythm problems
• have abnormal levels of potassium, calcium or magnesium in your blood
• develop severe skin reactions (itching, reddening of the skin or difficulty in breathing)
• develop signs of ‘adrenal insufficiency’ where the adrenal glands do not produce adequate amounts of certain steroid hormones such as cortisol (chronic, or long lasting fatigue, muscle weakness, loss of appetite, weight loss, abdominal pain)
• or your partner have had exposure to a sexually transmitted disease
• are unsure about the cause of your symptoms
• if the fungal infection does not improve, as alternative antifungal therapy may be needed
• have ever developed a severe skin rash or skin peeling, blistering and/or mouth sores after taking Fluconazole 150 mg Capsules

Serious skin reactions including drug reaction with eosinophilia and systemic symptoms (DRESS) have been reported in association with Fluconazole 150 mg Capsules treatment. Stop taking Fluconazole 150 mg Capsules and seek medical attention immediately if you notice any of the symptoms related to these serious skin reactions described in section 4.

Women only: If you

• have any abnormal or irregular vaginal bleeding or a blood stained discharge.
• have vulval or vaginal sores, ulcers or blisters.
• are experiencing lower abdominal pain or burning on passing urine.

Men only: If

• your sexual partner does not have vaginal thrush.
• you have penile sores, ulcers or blisters.
• you have an abnormal penile discharge (leakage).
• your penis has started to smell.
• you have pain on passing urine.

Other medicines and Fluconazole 150 mg Capsules

Tell your doctor or pharmacist if you are taking, have recently taken or might take any other medicines including medicines obtained without a prescription.

Tell your doctor immediately if you are taking astemizole, terfenadine (an antihistamine for treating allergies) or cisapride (used for stomach upsets) or pimozide (used for treating mental illness) or quinidine (used for treating heart arrhythmia) or erythromycin (an antibiotic for treating infections) as these should not be taken with Fluconazole 150 mg Capsules (see section: “Do not take Fluconazole 150 mg Capsules if you are”).

There are some medicines that may interact with Fluconazole 150 mg Capsules.

Make sure your doctor knows if you are taking any of the following medicines:

• nifedipine, isradipine, amlodipine, felodipine and losartan (for hypertension-high blood pressure)
• rifampicin, rifabutin (antibiotics for infections)
• medicines that thin the blood to prevent blood clots (Warfarin or similar medicines)
• benzodiazepines (midazolam, triazolam or similar medicines) used to help you sleep or for anxiety
• olaparib (used for treating ovarian cancer)
• chlorpropamide, glibenclamide, glipizide or tolbutamide (used to control diabetes)
• phenytoin, carbamazepine (used for treating fits)
• ciclosporin, everolimus, sirolimus or tacrolimus (to prevent transplant rejection)
• theophylline (used to control asthma)
• tofacitinib (used for treating rheumatoid arthritis)
• zidovudine, also known as AZT, or saquinavir (used in HIV-infected patients)
• prednisone (steroid)
• oral contraceptives
• alfentanil, fentanyl (used as anaesthetic)
• celecoxib, flurbiprofen, naproxen, ibuprofen, lornoxicam, meloxicam, diclofenac (Non-Steroidal Anti-Inflammatory Drugs (NSAID))
• amitriptyline, nortriptyline (used as anti-depressant)
• amphotericin B, voriconazole (anti-fungal)
• cyclophosphamide and vinca alkaloids (vincristine, vinblastine or similar medicines) used for treating cancer
• halofantrine (used for treating malaria)
• statins (atorvastatin, simvastatin and fluvastatin or similar medicines) used for reducing high cholesterol levels
• vitamin A (nutritional supplement)
• methadone (used for pain)
• ivacaftor (used for treating cystic fibrosis)
• amiodarone (used for treating uneven heartbeats, ‘arrhythmias’)
• hydrochlorothiazide (a diuretic)

Fluconazole 150 mg Capsules with food, drink and alcohol

You can take your medicine with or without a meal.

Pregnancy, breast-feeding and fertility

If you are pregnant or breast-feeding, think you may be pregnant or are planning to have a baby, ask your doctor or pharmacist for advice before taking this medicine.

You should not take Fluconazole 150 mg Capsules if you are pregnant, think you may be pregnant, are trying to become pregnant or breast-feeding, unless your doctor has told you so. You can continue breast-feeding after taking a single dose of 150 mg Fluconazole Capsules.

You should not breast-feed if you are taking a repeated dose of Fluconazole 150mg Capsules.

Fluconazole taken during the first trimester of pregnancy may increase the risk of miscarriage.

Fluconazole taken at low doses during the first trimester may slightly increase the risk of a baby being born with birth defects affecting the bones and/or muscles.

Driving and using machines

When driving vehicles or using machines, it should be taken into account that occasionally dizziness or fits may occur.

Fluconazole 150 mg Capsules contain lactose (milk sugar)

This medicine contains a small amount of lactose (milk sugar). If you have been told by your doctor that you have an intolerance to some sugars, please contact your doctor before taking this medicine.

This medicine contains less than 1 mmol sodium (23 mg) per capsule, that is to say essentially ‘sodium-free’.