Do not take Natrilix SR:

• if you are allergic to indapamide or any other sulfonamide or to any of the other ingredients of this medicine (listed in section 6),
• if you have severe kidney disease,
• if you have severe liver disease or suffer from a condition called hepatic encephalopathy (degenerative disease of the brain),
• if you have low potassium levels in your blood.

Warnings and precautions:

Talk to your doctor or pharmacist before taking Natrilix SR:

• if you have liver problems,
• if you have diabetes,
• if you suffer from gout,
• if you have any heart rhythm problems or problems with your kidneys,
• if you experience a decrease in vision or eye pain. These could be symptoms of fluid accumulation in the vascular layer of the eye (choroidal effusion) or an increase of pressure in your eye and can happen within hours to weeks of taking Natrilix SR. This can lead to permanent vision loss, if not treated. If you earlier have had a penicillin or sulfonamide allergy, you can be at higher risk of developing this,
• if you have muscle disorders including muscle pain, tenderness, weakness or cramps,
• if you need to have a test to check how well your parathyroid gland is working.

You should tell your doctor if you had photosensitivity reactions. Your doctor may give you blood tests to check for low sodium or potassium levels or high calcium levels.

If you think any of these situations may apply to you or you have any questions or doubts about taking your medicine, you should consult your doctor or pharmacist. Athletes should be aware that this medicine contains an active ingredient, which may give a positive reaction in doping tests.

Other medicines and Natrilix SR:

Tell your doctor or pharmacist if you are taking, have recently taken or might take any other medicines. You should not take Natrilix SR with lithium (used to treat depression) due to the risk of increased levels of lithium in the blood.

Make sure to tell your doctor if you are taking any of the following medicines, as special care may be required:

• medicines used for heart rhythm problems (e.g. quinidine, hydroquinidine, disopyramide, amiodarone, sotalol, ibutilide, dofetilide, digitalis, bretylium),
• medicines used to treat mental disorders such as depression, anxiety, schizophrenia… (e.g. tricyclic antidepressants, antipsychotic drugs, neuroleptics (such as amisulpride, sulpiride, sultopride, tiapride, haloperidol, droperidol)),
• bepridil (used to treat angina pectoris, a condition causing chest pain),
• cisapride (used to treat reduced movement of the gullet and stomach),
• diphemanil (used to treat gastro-intestinal problems
• antibiotics used to treat bacterial infections (e.g. sparfloxacin, moxifloxacin, erythromycin by injection),
• vincamine by injection (used to treat symptomatic cognitive disorders in elderly including memory loss),
• halofantrine (antiparasitic drug used to treat certain types of malaria),
• pentamidine (used to treat certain types of pneumonia),
• antihistamines used to treat allergic reactions, such as hay fever (e.g. mizolastine, astemizole, terfenadine),
• non-steroidal anti-inflammatory drugs for pain relief (e.g. ibuprofen) or high doses of acetylsalicylic acid,
• angiotensin converting enzyme (ACE) inhibitors (used to treat high blood pressure and heart failure),
• amphotericin B by injection (anti-fungal medicines),
• oral corticosteroids used to treat various conditions including severe asthma and rheumatoid arthritis,
• stimulant laxatives,
• baclofen (to treat muscle stiffness occurring in diseases such as multiple sclerosis),
• allopurinol (for the treatment of gout),
• potassium-sparing diuretics (e.g. amiloride, spironolactone, triamterene),
• metformin (to treat diabetes),
• iodinated contrast media (used for tests involving X-rays),
• calcium tablets or other calcium supplements,
• ciclosporin, tacrolimus or other medicines to depress the immune system after organ transplantation, to treat autoimmune diseases, or severe rheumatic or dermatological diseases,
• tetracosactide (to treat Crohn’s disease),
• methadone (used to treat addiction).

Pregnancy and breast-feeding:

If you are pregnant or breast-feeding, think you may be pregnant or are planning to have a baby, ask your doctor or pharmacist for advice before taking this medicine.

This medicine is not recommended during pregnancy. When a pregnancy is planned or confirmed, the switch to an alternative treatment should be initiated as soon as possible. Please tell your doctor if you are pregnant or wish to become pregnant. The active ingredient is excreted in milk. Breast-feeding is not recommended if you are taking this medicine.

Driving and using machines:

This medicine can cause side effects due to lowering of the blood pressure such as dizziness or tiredness (see section 4). These side effects are more likely to occur after initiation of the treatment and after dose increases. If this occurs, you should refrain from driving and other activities requiring alertness. However, under good control, these side effects are unlikely to occur.

Natrilix SR contains lactose monohydrate.

If you have been told by your doctor that you have an intolerance to some sugars, contact your doctor before taking this medicinal product.