Product Details

Product Information of Ibuprofen 400mg – Extra Strenght Tablets

What you need to know before you take Ibuprofen

Do not take Ibuprofen:
– if you are allergic to ibuprofen or any of the
other ingredients of this medicine (listed in
section 6).
– if you have had allergic reactions such
as asthma, runny nose, itchy skin rash or
swelling of the lips, face, tongue, or throat
after you have taken medicines containing
acetylsalicylic acid (such as aspirin) or other
drugs for pain and inflammation (NSAIDs).
– if you have suffered from gastrointestinal
bleeding or perforation related to previous
use of drugs for pain and inflammation
(NSAIDs)
– if you are suffering from an ulcer or
bleeding in the stomach or small intestine
(duodenum) or if you have had two or more
of these episodes in the past
– if you suffer from severe liver, kidney or
heart problems
– if you are in the last 3 months of pregnancy
– if you are suffering from significant
dehydration (caused by vomiting, diarrhoea
or insufficient fluid intake)
– if you have any active bleeding (including in
the brain)
– if you suffer from a condition of unknown
origin resulting in abnormal formation of
blood cells
Do not give Ibuprofen to children below 20 kg
body weight or younger than 6 years.

Warnings and precautions
Talk to your doctor before taking Ibuprofen
– if you have Systemic Lupus erythematosus
(SLE) or mixed connective tissue diseases
– if you have inherited a disorder of the red
blood pigment haemoglobin (porphyria)
– if you have chronic inflammatory intestinal
diseases such as inflammation of the colon
with ulcers (ulcerative colitis), inflammation
affecting the digestive tract (Crohn’s
disease) or other stomach or intestinal
diseases
– if you have disturbances in the formation of
blood cells
– if you have problems with normal blood
clotting mechanism
– if you suffer from allergies, hay fever,
asthma, chronic swelling of nasal mucosa,
sinuses, adenoids, or chronic obstructive
disorders of the respiratory tract because
the risk for developing narrowing of
the airways with difficulty in breathing
(bronchospasm) is greater
– if you have liver, kidney, or heart
problems
– if you have just had major surgery
– if you are in the first six months of
pregnancy
– if you are breast-feeding
– if you have an infection – please see
heading “Infections” below
Infections
Ibuprofen may hide signs of
infections such as fever and pain. It
is therefore possible that Ibuprofen
may delay appropriate treatment
of infection, which may lead to an
increased risk of complications. This
has been observed in pneumonia
caused by bacteria and bacterial
skin infections related to chickenpox.
If you take this medicine while you
have an infection and your symptoms
of the infection persist or worsen,
consult a doctor without delay.

Other medicines and Ibuprofen
Tell your doctor or pharmacist if you are taking,
have recently taken or might take any other
medicines.
Ibuprofen may affect or be affected by some
other medicines.
For example:
– other NSAIDs including COX-2 inhibitors,
since this may increase the risk of
gastrointestinal ulcers and bleeding
– anticoagulants (against clotting) such as
warfarin or heparin, since the effect of the
anticoagulant may be enhanced
– platelet aggregation inhibitors (against
clotting) such as clopidogrel and ticlopidine
– methotrexate (used to treat cancer and
auto-immune diseases)
– digoxin (for treatment of various heart
conditions) since the effect of digoxin may
be enhanced
– phenytoin (used in prevention of the
occurrence of epileptic seizures) since the
effect of phenytoin may be enhanced
– lithium (used to treat depression and mania)
since the effect of lithium may be enhanced
– diuretics (water tablets) since the effect of
the diuretics may be weakened,
– potassium-sparing diuretics since this may
lead to hyperkalaemia
– medicines that reduce high blood pressure
(ACE-inhibitors such as captopril, betablockers such as atenolol medicines,
angiotensin-II receptor antagonists such as
losartan)
– cholestyramine (used in the treatment of
high cholesterol)
– aminoglycosides (medicines against certain
types of bacteria) since NSAIDs may
decrease excretion of aminoglycosides
– SSRIs (medicines against depression)
such as paroxetin, sertralin, citalopram as
these may increase risk of gastrointestinal
bleeding
– ciclosporine, tacrolimus (for immunosuppression after organ transplant) since
kidney damage may occur
– zidovudine or ritanovir (used to treat
patients with HIV)
– mifepristone since NSAIDs can reduce the
effect of mifepristone
– probenecid or sulfinpyrazone (for treating
gout) since the excretion of ibuprofen may
be delayed
– quinolone antibiotics since the risk of
convulsions (fits) may be increased
– sulphonylureas (to treat type 2 diabetes)
since the blood sugar levels can be affected
– glucocorticoids (used against inflammations)
since this may increase the risk of
gastrointestinal ulcers or bleeding
– bisphosphonates (used in osteoporosis,
Paget’s disease and to reduce high blood
calcium levels)
– oxpentifylline ((pentoxifylline) used in the
treatment of circulatory disease of the
arteries of the legs or arms)
– baclofen (a muscle relaxant) because of
elevated baclofen toxicity
– Gingko biloba herbal medicine (there is a
chance you may bleed more easily if you
are taking this with ibuprofen).
– voriconazole and fluconazole (CYP2C9
inhibitors) (used for fungal infections),
since the effect of ibuprofen may increase.
Reduction of the ibuprofen dose should be
considered, particularly when high-dose
ibuprofen is used with either voriconazole or
fluconazole.
Some other medicines may also affect or be
affected by the treatment of Ibuprofen. You
should therefore always seek the advice of your
doctor or pharmacist before you use Ibuprofen
with other medicines.
Ibuprofen with alcohol
Avoid alcohol since it may enhance the side
effects of Ibuprofen, especially those affecting
the stomach, intestines or central nervous
system.
Pregnancy, breast-feeding and fertility
If you are pregnant or breast-feeding, think
you may be pregnant or are planning to have a
baby, ask your doctor or pharmacist for advice
before taking this medicine.
Ibuprofen must not be taken in the last 3
months of pregnancy since it may cause major
heart, lung and kidney disorders in the unborn
child. If used at the end of pregnancy, it may
cause bleeding tendencies in both mother
and child and weaken the strength of uterine
contractions delaying the onset of delivery.
Treatment during the first 6 months of
pregnancy will only be prescribed by your
doctor if clearly necessary.
Ibuprofen may make it more difficult to become
pregnant. You should inform your doctor if you
are planning to become pregnant or if you have
problems becoming pregnant.
Ibuprofen appears in breast milk in a very small
amount and breastfeeding will usually not need
to be stopped during short-term treatments. If,
however, longer treatment is prescribed, early
weaning should be considered.
Driving and using machines
Ibuprofen generally has no adverse effects
on the ability to drive or operate machinery.
However since at high dosage side effects such
as fatigue, somnolence, vertigo (reported as
common) and visual disturbances (reported as
uncommon) may be experienced, the ability
to take part actively in road traffic or operate
machinery may be impaired in individual cases.
This effect is potentiated by simultaneous
consumption of alcohol