Product Details

Gliclazide 80mg Tablets Product Information

What you need to know before you take Gliclazide tablets
Do not take Gliclazide tablets and tell your doctor if you:
• are allergic to gliclazide or any of the ingredients of this medicine (listed in section 6), to other medicines of the same group (sulfonylureas) or other related medicines (hypoglycaemic sulfonamides). An allergic reaction may include a rash, itching,
difficulty breathing or swelling of the face, lips, throat or tongue
• are breast feeding
• have severe liver or kidney disease
• have porphyria (a hereditary disease affecting the liver or bone marrow)
• have ever had a severe diabetic reaction (such as “acidosis” or diabetic coma).
• have Type I diabetes
• are diabetic and need an operation, suffered a severe trauma
or infection
• take miconazole (for fungal infections).
Warnings and precautions
Talk to your doctor or pharmacist before taking Gliclazide tablets if you:
• have liver or kidney problems

• have an inherited condition where your red blood cells don’t produce enough of the enzyme G6PD (glucose 6 phosphate dehydrogenase)
• suffer from particular hormone-induced disorders (functional
disorders of the thyroid gland, of the pituitary gland or adrenal
cortex)
• are at risk of developing low blood sugar (hypoglycaemia)
– take meals irregularly or skip meals altogether, are fasting,
malnourished, change your diet, increase your physical activity
and carbohydrate intake does not match this increase, drink
alcohol, especially in combination with skipped meals
• take other medicines or natural remedies at the same time
• take too high doses of gliclazide.
You should observe the treatment plan prescribed by your
doctor to achieve proper blood sugar levels. This means, apart
from regular tablet intake, to observe the dietary regiment, have
physical exercise and, where necessary, reduce weight. During
gliclazide treatment, regular monitoring of your blood (and
possibly urine) sugar level and also your glycated haemoglobin
(HbA1c) is necessary.
Cases of acute porphyria have been described with some other
sulfonylurea drugs, in patients who have porphyria (inherited
genetic disorders with accumulation in the body of porphyrins or
porphyrin precursors).
Other medicines and Gliclazide tablets
Tell your doctor or pharmacist if you are taking, have
recently taken or might take any other medicines, including
medicines obtained without a prescription.
Especially:
• other medicines used to treat high blood sugar (oral
antidiabetic, GLP-1 receptor inhibitors or insulin)
• antibiotics (sulfonamides, clarithromycin)
• medicines to treat high blood pressure such as beta blockers
(e.g. propranolol, atenolol), ACE inhibitors (e.g. captopril),
Angiotensin-II antagonists (e.g. losartan), nifedipine, diazoxide
• medicines used to treat infections such as co-trimoxazole,
fluconazole, rifampicin, chloramphenicol, oral forms of
miconazole (see section 2), sulfonamides such as
sulfafurazole or tetracycline compounds (e.g. tetracycline)
• medicines used to prevent blood clotting (e.g. warfarin)
• medicines used to treat depression such as monoamine oxidase
inhibitors (MAOIs e.g. moclobemide)
• medicines used to treat mental health problems such as lithium,
phenothiazine derivatives (e.g. prochlorperazine)
• corticosteroids (e.g. prednisolone), glucocorticoids and
tetracosactrin used to reduce inflammation in the body
• phenylbutazone, azapropazone and other NSAIDs (nonsteroidal anti-inflammatory drugs)
• diuretics (water tablets) such as bendroflumethiazide,
hydrochlorothiazide, furosemide
• oral contraceptives (the “pill”)
• salicylates (e.g. aspirin used for muscular or skeletal disorders)
• sulfinpyrazone (used for gout)
• aminoglutethimide (used to treat breast or prostate cancer)
• hormones such as testosterone, octreotide or thyroid hormones
(e.g. thyroxine)
• cimetidine (used to treat stomach ulcers)
• clofibrate (used to treat high cholesterol in the blood)
• disopyramide (for irregular heartbeats)
• laxatives
• other medicines used to treat high blood sugar
• medicines containing alcohol

• chlorpromazine to treat disorders of the central nervous system
• medicines to treat asthma or used during labour (intravenous
salbutamol, ritodrine and terbutaline)
• danazol to treat breast disorders, heavy menstrual bleeding and
endometriosis
• St John’s Wort (Hypericum perforatum) preparations
Blood glucose disturbance (low blood sugar and high blood sugar)
can occur when a medicine belonging to a class of antibiotics called
fluoroquinolones is taken at the same time as Gliclazide tablets,
especially in elderly patients.
Gliclazide tablets with alcohol
Patients should not consume alcohol in combination with Gliclazide
tablets.
Pregnancy and breast-feeding
Gliclazide tablets are not recommended for use during pregnancy. If you
are pregnant, think you may be pregnant or are planning to have a baby,
ask your doctor for advice before taking this medicine.
You must not take Gliclazide tablets while you are breastfeeding.
Driving and using machines
Provided your blood glucose levels are satisfactorily controlled on
Gliclazide tablets, your ability to drive or use machines should not be
affected. However, if your blood glucose levels become too low, this
could adversely affect your concentration, and therefore your ability to
perform these tasks.
Ask your doctor whether you can drive a car if you:
• have frequent episodes of low blood sugar (hypoglycaemia),
• have few or no warning signals of low blood sugar.