Product Details

What you need to know before you take Advant tablets

Do not take Advant tablets
• if you are allergic to candesartan cilexetil or any of the other ingredients of this medicine (listed in section 6).
• if you are more than 3 months pregnant (it is also better to avoid Amias in early pregnancy – see pregnancy section).
• if you have severe liver disease or biliary obstruction (a problem with the drainage of the bile from the gall bladder).
• if the patient is a child under 1 year of age.
• if you are taking a blood pressure lowering medicine containing aliskiren and you have diabetes or impaired kidney function.
If you are not sure if any of these apply to you, talk to your doctor or pharmacist before taking Advant tablets

Warnings and Precautions

Talk to your doctor before taking Advant tablets:
• if you have heart, liver or kidney problems, or are on dialysis.
• if you have recently had a kidney transplant.
• if you are vomiting, have recently had severe vomiting, or have diarrhoea.
• if you have a disease of the adrenal gland called Conn’s syndrome (also called primary hyperaldosteronism).
• if you have low blood pressure.
• if you have ever had a stroke.
• you must tell your doctor if you think you are (or might become) pregnant. Amias is not recommended in early pregnancy, and must not be taken if you are more than 3 months pregnant, as it may cause serious harm to your baby if used at that stage (see pregnancy section).
• if you are taking any of the following medicines used to treat high blood pressure:
– an ACE-inhibitor (for example enalapril, lisinopril, ramipril), in particular if you have diabetes related kidney problems.
– Aliskiren.
• if you are taking an ACE-inhibitor together with a medicine which belongs to the class of medicines known as mineralocorticoid receptors antagonists (MRA). These medicines are for the treatment of heart failure (see “Other medicines and Amias”).
Your doctor may check your kidney function, blood pressure, and the amount of electrolytes (e.g. potassium) in your blood at regular intervals.
See also information under the heading “Do not take Advant tablets”.
Your doctor may want to see you more often and do some tests if you have any of these conditions.
If you are going to have an operation, tell your doctor or dentist that you are taking Amias. This is because Advant tablets, when combined with some anaesthetics, may cause a drop in blood pressure.
Children and adolescents
Advant tablets has been studied in children. For more information, talk to your doctor. Advant tablets must not be given to children under 1 year of age due to the potential risk to the developing kidneys.
Other medicines and Advant tablets
Tell your doctor or pharmacist if you are using, have recently used or might use any other medicines.
Advant tablets can affect the way some other medicines work and some medicines can have an effect on Advant tablets. If you are using certain medicines, your doctor may need to do blood tests from time to time.
In particular, tell your doctor if you are using any of the following medicines as your doctor may need to change your dose and/or take other precautions:
• Other medicines to help lower your blood pressure, including beta-blockers, diazoxide and ACE inhibitors such as enalapril, captopril, lisinopril or ramipril.
• Non-steroidal anti-inflammatory drugs (NSAIDs) such as ibuprofen, naproxen, diclofenac, celecoxib or etoricoxib (medicines to relieve pain and inflammation).
• Acetylsalicylic acid (if you are taking more than 3 g each day) (medicine to relieve pain and inflammation).
• Potassium supplements or salt substitutes containing potassium (medicines that increase the amount of potassium in your blood).
• Heparin (a medicine for thinning the blood).

• Water tablets (diuretics).
• Lithium (a medicine for mental health problems).
• If you are taking an ACE-inhibitor or aliskiren (see also information under the headings “Do not
take Amias” and “Warnings and precautions”)
• If you are being treated with an ACE-inhibitor together with certain other medicines to treat your
heart failure, which are known as mineralocorticoid receptors antagonists (MRA) (for example
spironolactone, eplerenone).
Advant tablets with food and drink and alcohol
• You can take Advant tablets with or without food.
• When you are prescribed Advant tablets, discuss with your doctor before drinking alcohol. Alcohol may make you feel faint or dizzy.
Pregnancy and breast-feeding
Pregnancy
You must tell your doctor if you think you are (or might become) pregnant. Your doctor will normally advise you to stop taking Amias before you become pregnant or as soon as you know you are pregnant
and will advise you to take another medicine instead of Amias. Amias is not recommended in early pregnancy, and must not be taken when more than 3 months pregnant, as it may cause serious harm to
your baby if used after the third month of pregnancy.
Breast-feeding
Tell your doctor if you are breast-feeding or about to start breast-feeding. Advant tablets is not recommended for mothers who are breast-feeding, and your doctor may choose another treatment for you if you wish
to breast-feed, especially if your baby is newborn, or was born prematurely.
Driving and using machines
Some people may feel tired or dizzy when taking Advant tablets. If this happens to you, do not drive or use
any tools or machines.
Amias contains lactose
Lactose is a type of sugar. If you have been told by your doctor that you have an intolerance to some sugars, contact your doctor before taking this medicine.

How to store Advant tablets
• Keep this medicine out of the sight and reach of children.
• Do not use this medicine after the expiry date which is stated on the carton label and blister foil after (EXP). The expiry date refers to the last day of that month.
• Do not store above 30ºC.
Do not throw away any medicine via wastewater or household waste. Ask your pharmacist how to throw away medicines you no longer use. These measures will help to protect the environment.