Side Effects

What side effects are possible with Advantec Tablets?

Many medications can cause side effects. A side effect is an unwanted response to a medication when it is taken in normal doses. Side effects can be mild or severe, temporary or permanent.

The side effects listed below are not experienced by everyone who takes this medication. If you are concerned about side effects, discuss the risks and benefits of this medication with your doctor.

The following side effects have been reported by at least 1% of people taking this medication. Many of these side effects can be managed, and some may go away on their own over time.

Contact your doctor if you experience these side effects and they are severe or bothersome. Your pharmacist may be able to advise you on managing side effects.

• back or leg pain
• constipation
• decreased appetite
• decreased interest in sexual activity
• diarrhea
• dizziness or lightheadedness when rising from a lying or sitting position
• drowsiness
• • headache
  • muscle cramps, pain
  • nausea
  • pins and needles feeling in your fingers
  • sun sensitivity
  • trouble sleeping
  • vomiting

  Although most of these side effects listed below don’t happen very often, they could lead to serious problems if you do not seek medical attention.

  Check with your doctor as soon as possible if any of the following side effects occur:

  • changes in vision (blurred vision, increased eye pressure, eye pain)
  • increased heart rate
  • increased frequency of cold symptoms (ear, head, and nose congestion; sneezing; sore throat; fever)
  • signs of anemia (low red blood cells; e.g., dizziness, pale skin, unusual tiredness or weakness, shortness of breath)
  • signs of clotting problems (e.g., unusual nosebleeds, bruising, blood in urine, coughing blood, bleeding gums, cuts that don’t stop bleeding)
  • signs of electrolyte changes (e.g., confusion, drowsiness, dry mouth, muscle fatigue, nausea, thirst, weakness)
  • signs of kidney problems (e.g., increased urination at night, decreased urine production, blood in the urine)
  • signs of kidney failure (e.g., decreased urine production, swelling, fatigue, abdominal pain)
  • signs of liver problems (e.g., nausea, vomiting, diarrhea, loss of appetite, weight loss, yellowing of the skin or whites of the eyes, dark urine, pale stools)
  • signs of pancreatitis (e.g., abdominal pain on the upper left side, back pain, nausea, fever, chills, rapid heartbeat, swollen abdomen)
  • swelling of the hands, feet, or ankles
  • symptoms of high blood sugar (e.g., frequent urination, increased thirst, excessive eating, unexplained weight loss, poor wound healing, infections, fruity breath odour)
  • • unexplained muscle pain, tenderness, or weakness

    Stop taking the medication and seek immediate medical attention if any of the following occur:

    • signs of a severe skin reaction such as blistering, peeling, a rash covering a large area of the body, a rash that spreads quickly, or a rash combined with fever or discomfort
    • signs of a serious allergic reaction (e.g., abdominal cramps, difficulty breathing, nausea and vomiting, or swelling of the face and throat)

    Some people may experience side effects other than those listed. Check with your doctor if you notice any symptom that worries you while you are taking this medication.

    Are there any other precautions or warnings for this medication?

    Before you begin taking a medication, be sure to inform your doctor of any medical conditions or allergies you may have, any medications you are taking, whether you are pregnant or breast-feeding, and any other significant facts about your health. These factors may affect how you should use this medication.

  • What other drugs could interact with this medication?

    There may be an interaction between candesartan – hydrochlorothiazide and any of the following:

    • aclidinium
    • alcohol
    • aldesleukin
    • aliskiren
    • allopurinol
    • alpha agonists (e.g., clonidine, methyldopa)
    • alpha blockers (e.g., alfuzosin, doxazosin, tamsulosin)
    • amantadine
    • amifostine
    • amphetamines (e.g., dextroamphetamine, lisdexamphetamine)
    • angiotensin converting enzyme inhibitors (ACEIs; captopril, enalapril, ramipril)
    • angiotensin receptor blockers (ARBs; e.g., candasartan, irbesartan, losartan)
    • antihistamines (e.g., cetirizine, doxylamine, diphenhydramine, hydroxyzine, loratadine)
    • antipsychotics (e.g., chlorpromazine, clozapine, haloperidol, olanzapine, quetiapine, risperidone)
    • atropine
    • azelastine
    • barbiturates (e.g., secobarbital, phenobarbital)
    • belladonna
    • benztropine
    • beta-adrenergic blockers (e.g., atenolol, propranolol, sotalol)
    • beta-2 agonists (e.g., salbutamol, formoterol, terbutaline)
    • brimonidine
    • calcitriol
    • calcium channel blockers (e.g., amlodipine, diltiazem, nifedipine, verapamil)
    • calcium supplements
    • carbamazepine
    • cholestyramine
    • inhaled corticosteroids (e.g., budesonide, ciclesonide, fluticasone)
    • oral corticosteroids (e.g., dexamethasone, hydrocortisone, prednisone)
    • ciprofloxacin