Side Effects

Side Effects of Letrozole 2.5mg Tablets

Possible side effects

Like all medicines, this medicine can cause side effects, although not everybody gets them. Most of the side effects are mild to moderate and will generally disappear after a few days to a few weeks of treatment. Some of these side effects, such as hot flushes, hair loss or vaginal bleeding, may be due to the lack of oestrogens in your body. Do not be alarmed by this list of possible side effects. You may not experience any of them. Some side effects could be serious: Rare side effects (may affect up to 1 in 1000 people) – Difficulty breathing, chest pain, fainting, rapid heart rate, bluish skin discoloration, or sudden arm, leg or foot pain (signs that a blood clot may have formed). – Rupture of a tendon (connective tissues that connect muscles to bones). Uncommon side effects (may affect up to 1 in 100 people): – Severe persistent blurred vision – Severe fever, chills or mouth ulcers due to infections (lack of white blood cells) – Swellling and redness along a vein which is extremely tender and possibly painful when touched. – Sudden oppressive chest pain (sign of a heart disorder) – Weakness, paralysis or loss of feeling in any part of the body (particularly arm or leg), loss of coordination, nausea, or difficulty speaking or breathing (sign of a brain disorder, e.g. stroke). – Inflammation of a tendon or tendonitis (connective tissues that connect muscles to bones) If any of the above occurs, tell your doctor straight away. You should also inform the doctor straight away if you experience any of the following symptoms during treatment with Letrozole Tablets: – swelling mainly of the face and throat (signs of allergic reaction). – yellow skin and eyes, nausea, loss of appetite, dark-coloured urine (signs of hepatitis). – rash, red skin, blistering of the lips, eyes or mouth, skin peeling, fever (signs of skin disorder). Some side effects are very common (may affect more than 1 in 10 people) – Hot flushes – Increased level of cholesterol (hypercholesterolemia) – Fatigue and weakness – Increased sweating – Malaise (generally feeling unwell) – Pain in joints (arthralgia) If any of these affects you severely, tell your doctor. Some side effects are common (may affect up to 1 in 10 people) – Skin rash – Headache – Dizziness – Gastrointestinal disorders such as nausea, vomiting, indigestion, constipation, diarrhoea – Increase in or loss of appetite – Pain in muscles – Thinning or wasting of your bones (osteoporosis), leading to bone fractures in some cases (see also “Follow-up during Letrozole Tablets treatment” in section 3) – Swelling of arms, hands, feet, ankles (oedema) – Depression – Weight increase – Hair loss – Raised blood pressure (hypertension) – Abdominal pain – Dry skin – Vaginal bleeding – Palpitations – Joint stiffness (arthritis) – Chest pain – Pain in bones If any of these affects you severely, tell your doctor. Other side effects are uncommon (may affect up to 1 in 100 people) – Nervous disorders such as anxiety, nervousness, irritability, drowsiness, memory problems, insomnia – Pain or burning sensation in the hands or wrist (carpal tunnel syndrome) – Impairment of sensation, especially that of touch , tingling or numbness – Eye disorders such as blurred vision, eye irritation – Rapid heart rate – Skin disorders such as itching (pruritus) – Hives – Vaginal discharge or dryness – Breast pain – Thirst, taste disorder, dry mouth – Dryness of mucous membranes – Weight decrease – Urinary tract infection, increased frequency of urination – Cough – Increased level of enzymes – Yellowing of the skin and eyes – High blood levels of bilirubin (a breakdown product of red blood cells) – Tumour pain – Inflammation of the mouth and lips (Stomatitis) – General oedema – Fever – Shortness of breath Side effects with frequency not known Trigger finger, a condition in which your finger or thumb catches in a bent position. If any of these affects you severely, tell your doctor. Reporting of side effects If you get any side effects, talk to your doctor, pharmacist or nurse. This includes any possible side effects not listed in this leaflet.