Product Details

Product Information of Simbrinza Eye Drops

What you need to know before you use SIMBRINZA

Do not use SIMBRINZA – if you are allergic to brinzolamide or brimonidine tartrate or any of the other ingredients of this medicine (listed in section 6) – if you are allergic to sulphonamides (examples include medicines used to treat diabetes and infections and also diuretics (water tablets)) – if you are taking a monoamine oxidase (MAO) inhibitors (examples include medicines to treat depression or Parkinson’s disease) or certain antidepressants. You must inform your doctor if you are taking any antidepressant medicines – if you have severe kidney problems – if you have too much acidity in your blood (a condition called hyperchloraemic acidosis) – in babies and infants aged less than 2 years. Warnings and precautions Talk to your doctor, optometrist (optician) or pharmacist before using SIMBRINZA if you have now or have had in the past: – liver problems – a type of high pressure in the eyes called narrow-angle glaucoma – dry eyes or cornea problems 2 – coronary heart disease (symptoms can include chest pain or tightness, breathlessness or choking), heart failure, high or low blood pressure – depression – disturbed or poor blood circulation (such as Raynaud’s disease, Raynaud’s syndrome or cerebral insufficiency). If you wear soft contact lenses, do not use the drops with your lenses in. See section “Wearing contact lenses – SIMBRINZA contains benzalkonium chloride” below). Children and adolescents SIMBRINZA is not intended for use by children and adolescents aged below 18 years because it has not been studied in this age group. It is particularly important that the medicine is not used in children under the age of 2 years (see section ‘Do not use SIMBRINZA’ above) because it is unlikely to be safe. Other medicines and SIMBRINZA Tell your doctor, optometrist (optician) or pharmacist if you are using, have recently used, or might use any other medicines. SIMBRINZA can affect or be affected by other medicines you are using, including other eye drops for the treatment of glaucoma. Tell your doctor if you are taking or intend to take any of the following medicines: – medicines to lower blood pressure – heart medicines including digoxin (used to treat heart conditions) – other medicines for glaucoma that also treat altitude sickness known as acetazolamide, methazolamide and dorzolamide – medicines that can affect the metabolism, such as chlorpromazine, methylphenidate and reserpine – antiviral, antiretroviral (used to treat Human Immunodeficiency Virus (HIV)) or antibiotic medicines – antiyeast or antifungal medicines – monoamine oxidase (MAO) inhibitors, or antidepressants including amitriptyline, nortriptyline, clomipramine, mianserin, venlafaxine and duloxetine – anaesthetics – sedatives, opiates, or barbiturates You should also tell your doctor if the dose of any of your current medicines is changed. SIMBRINZA with alcohol If you regularly consume alcohol, ask your doctor, optometrist (optician) or pharmacist for advice before taking this medicine. SIMBRINZA can be affected by alcohol. Pregnancy and breast-feeding If you are pregnant, think you may be pregnant or are planning to have a baby, ask your doctor, optometrist (optician) or pharmacist for advice before taking this medicine. Women who may become pregnant are advised to use effective contraception during SIMBRINZA treatment. The use of SIMBRINZA is not recommended during pregnancy. Do not use SIMBRINZA unless clearly indicated by your doctor. If you are breast-feeding, SIMBRINZA may pass into your milk. The use of SIMBRINZA is not recommended during breast-feeding. Driving and using machines You may find that your vision is blurred or abnormal for a time just after using SIMBRINZA. SIMBRINZA may also cause dizziness, drowsiness or tiredness in some patients. 3 Do not drive or use machines until the symptoms are cleared. Wearing contact lenses – SIMBRINZA contains benzalkonium chloride This medicine contains 0.15 mg benzalkonium chloride in each 5 ml, which is equivalent to 0.03 mg/ml. Benzalkonium chloride may be absorbed by soft contact lenses and may change the colour of the contact lenses. You should remove contact lenses before using this medicine and put them back 15 minutes afterwards. Benzalkonium chloride may also cause eye irritation, especially if you have dry eyes or a disorder of the cornea (the clear layer at the front of the eye). If you feel abnormal eye sensation, stinging or pain in the eye after using this medicine, talk to your doctor.