Product Details

What you need to know before you take Tadalafil
Do not take Tadalafil if you:
­ are allergic to tadalafil or any of the other ingredients of this medicine (listed in section 6).
­ are taking any form of organic nitrate or nitric oxide donors such as amyl nitrite. This is a group
of medicines (“nitrates”) used in the treatment of angina pectoris (“chest pain”). Tadalafil has been shown to increase the effects of these medicines. If you are taking any form of nitrate or are unsure tell your doctor.
­ have serious heart disease or recently had a heart attack within the last 90 days.
­ have recently had a stroke within the last 6 months.
­ have low blood pressure or uncontrolled high blood pressure.
­ ever had loss of vision because of non-arteritic anterior ischemic optic neuropathy (NAION), a condition described as “stroke of the eye”.
­ are taking riociguat. This drug is used to treat pulmonary arterial hypertension (i.e., high blood pressure in the lungs) and chronic thromboembolic pulmonary hypertension (i.e., high blood pressure in the lungs secondary to blood clots). PDE5 inhibitors, such as tadalafil, have been shown to increase the hypotensive effects of this medicine. If you are taking riociguat or are unsure tell your doctor.
Warnings and precautions
Talk to your doctor or pharmacist before taking Tadalafil.
Be aware that sexual activity carries a possible risk to patients with heart disease because it puts an extra strain on your heart. If you have a heart problem you should tell your doctor.
Before taking the tablets, tell your doctor if you have: ­ sickle cell anaemia (an abnormality of red blood cells).  multiple myeloma (cancer of the bone marrow).
­ leukaemia (cancer of the blood cells). any deformation of your penis.
­ a serious liver problem. ­ a severe kidney problem.
Since benign prostatic hyperplasia and prostate cancer may have the same symptoms, your doctor will check you for prostate cancer before starting treatment with Tadalafil for benign prostatic hyperplasia.
Tadalafil does not treat prostate cancer.
It is not known if Tadalafil is effective in patients who have had:
­ pelvic surgery. ­ removal of all or part of the prostate gland in which nerves of the prostate are cut (radical nonnerve-sparing prostatectomy).
If you experience sudden decrease or loss of vision, stop taking Tadalafil and contact your doctor immediately.
Decreased or sudden hearing loss has been noted in some patients taking tadalafil. Although it is not
known if the event is directly related to tadalafil, if you experience decreased or sudden hearing loss,
stop taking Tadalafil and contact your doctor immediately.
Tadalafil should not be used as treatment of erectile dysfunction or benign prostatic hyperplasia
by women because these are health problems specific to men.
Children and adolescents
Tadalafil is not intended for use by children and adolescents under the age of 18.
Other medicines and Tadalafil
Tell your doctor or pharmacist if you are taking, have recently taken or might take any other
medicines.
Do not take Tadalafil if you are already taking nitrates.
Some medicines may be affected by Tadalafil or they may affect how well Tadalafil will work. Tell
your doctor or pharmacist if you are already taking:
­ an alpha blocker (used to treat high blood pressure or urinary symptoms associated with benign
prostatic hyperplasia).
­ other medicines to treat high blood pressure.
­ riociguat.
­ a 5- alpha reductase inhibitor (used to treat benign prostatic hyperplasia).
­ medicines such as ketoconazole tablets (to treat fungal infections) and protease inhibitors for
treatment of AIDS or HIV infection.
­ phenobarbital, phenytoin and carbamazepine (anticonvulsant medicines).
­ rifampicin, erythromycin , clarithromycin or itraconazole.
­ other treatments for erectile dysfunction.
Tadalafil with drink and alcohol
Information on the effect of alcohol is in section 3. Grapefruit juice may affect how well Tadalafil
will work and should be taken with caution. Talk to your doctor for further information.
Pregnancy, breastfeeding and Fertility
Pregnancy
If you are pregnant or breast-feeding, think you may be pregnant or are planning to have a baby, ask
your doctor for advice before taking this medicine. Do not take tadalafil when pregnant, unless it is
strictly necessary and you have discussed this with your doctor.
Breastfeeding
Do not breastfeed while taking these tablets as it is not known if the medicine passes into human
breast milk. Ask your doctor or pharmacist for advice before taking any medicine while pregnant or
breastfeeding.
Fertility
When dogs were treated there was reduced sperm development in the testes. A reduction in sperm was
seen in some men. These effects are unlikely to lead to a lack of fertility.
Driving and using machines
Some men taking tadalafil in clinical studies have reported dizziness. Check carefully how you react
to the tablets before driving or using machines.
Tadalafil contains lactose:
If you have an intolerance to some sugars, contact your doctor before taking this medicine